‘Certainly, that is definitely about correct. I hunt for a Actual physical idea of biological techniques within a base-up way. I believe you could distinguish 3 strains of analysis in my team in the mean time. The 1st issues chromosome framework: How would you get a metre-extended DNA polymer folded and organised in this type of microscopic mobile? We have produced visualisation techniques that allow for us to study how, by way of example, SMC proteins loop DNA (online video on Youtube) in order to Develop up chromosomes.
Our team scientific tests bacterial mobile division and it is aiming to represent a ‘base up biology’ in synthetic cells that can autonomously divide. Our most important fascination lies in cell division, chromatin structure, and spatial Command.
, Groningen scientists existing the effects in their endeavours to make labs much more sustainable and provide strategies for other labs.
2007, to start with actual-time detection of strand Trade in homologous recombination by RecA; discovery of a lower persistence duration of ends of microtubules; and solved the mechanism of biosensing with carbon nanotubes
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Cornelis (Cees) Dekker (Haren, 7 april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en achieved 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
We use nanofabricated microfluidic buildings to sample spatial boundaries for microbes and biomimetic vesicles with reconstituted protein networks which evaluate the basic part of spatial confinement on the molecular and cellular level. Our projects include the subsequent:
He also found time to put in writing a number of textbooks, send Practically forty thousand tweets and lead An effective investigate group at Delft https://www.ceesdekker.net University of Technology. ‘It doesn’t truly feel like do the job’, he states. ‘I’m just terribly curious.’
‘You should not just think about the concerns of tomorrow, but additionally think about the queries in the day right after tomorrow’
Bulk-surface area coupling identifies the mechanistic link involving Min-protein styles in vivo As well as in vitro
Screening pseudotopological and nontopological products for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
Quite a few new phenomena had been found out, and he and his exploration group founded a leading posture In this particular field of exploration. Dekker and his analysis team uncovered new physics of nanotubes as well as explored the feasibility of molecular electronics. In 1998, they ended up the initial to make a transistor depending on only one nanotube molecule.
2005, discovery of your mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extensive-assortment conformational changes in Mre11/DNA mend complexes; and first power measurements with a DNA molecule within a nanopore
Last but not least, I will briefly sketch a few of our Tips to examine the making of artificial cells, exclusively our first steps to ascertain artificial mobile division.